How to Add Sermorelin and NAD+ to Your Longevity Clinic
A practical clinical and compliance guide for new and existing longevity companies.
As demand for longevity care continues to grow, many clinics are exploring how to introduce two commonly requested therapies: NAD+ and Sermorelin. These treatments can be valuable additions to programs focused on energy, recovery, healthy aging, and metabolic support. But adding them requires thoughtful planning across clinical workflows, pharmacy coordination, documentation, and regulatory alignment.
Related Content: How to Start A Longevity Clinic (Step-by-Step Guide)
That growing interest shows up clearly in search behavior.
NAD+ and Sermorelin Search Data
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Patients are actively searching for these longevity treatments. As of August 2025, searches for “Sermorelin” were up 233% compared to August 2024. Searches for NAD+ were up 122% compared to August of 2024. (Google Ads Keyword Planner Search Data, August 2024 - 2025).
What Do NAD+ and Sermorelin Do?
Before we dive right in, let’s do a quick recap on the mechanisms of action for NAD+ and Sermorelin.
What Does NAD+ Do?
Nicotinamide adenine dinucleotide (NAD+) is a naturally occurring coenzyme in all cells, central to energy metabolism and involved in processes such as DNA repair. Because NAD+ levels decline with age and stress, many longevity programs include NAD+-supportive therapies
Clinics may administer NAD+ via IV, intramuscular, or subcutaneous injections—the latter well-suited for virtual-first care with proper patient education. Timing varies by clinic, supporting either energy or recovery-focused goals.
What Does Sermorelin Do?
Sermorelin is a synthetic peptide analog of growth hormone–releasing hormone (GHRH 1–29) that stimulates the pituitary gland to increase production and secretion of endogenous growth hormone.
Clinics may include it in longevity programs that address age-related hormone decline, such as energy, recovery, and body composition, typically as a self-administered subcutaneous therapy. Many clinicians prefer evening use because growth hormone secretion tends to peak during sleep, though timing can vary by practice.
How to Offer Virtual NAD+ Therapy Safely
Integrating NAD+ into a clinic requires a structured approach that supports safety, consistency, and regulatory compliance.
Standardized Intake and Assessment
A longevity intake typically includes a review of wellness goals, medical history, medication use, and prior therapies. This gives clinicians a clear foundation for determining whether NAD+ is appropriate and how it should be incorporated into a broader plan. Clinics generally document the reasoning behind initiating therapy to align with state telehealth expectations.
Defined Pathways for Different Delivery Methods
While individual protocols vary, NAD+ programs generally follow three models:
IV NAD+: Most suitable for in-person or hybrid environments with licensed clinical supervision where required by state regulations.
Subcutaneous NAD+: A common option for telehealth programs, requiring patient education on administration, handling, and expectations.
Oral NAD+ Precursors: Supplements that may complement other therapies but still require clinician oversight.
Each clinic should maintain internal, evidence-informed protocols approved by a supervising clinician.
NAD+ Telehealth Program Setup Considerations
A compliant virtual NAD+ program typically includes:
A telehealth intake process aligned with state-level licensure rules
Clear written instructions for at-home subcutaneous administration
A defined process for handling patient questions and concerns
Scheduled follow-ups after initiation and at periodic intervals
Consistent documentation within an EHR
Telehealth prescribing occurs in the patient’s state, so clinicians must be licensed accordingly.
Patient Education and Support
Patients should receive program or treatment materials that explain:
How the therapy supports their longevity goals
Proper storage and handling
What to expect during early administrations
How to reach clinical support
Clinics offering at-home injectable therapies should also plan for basic supply needs. Most compounding pharmacies include syringes and wipes with each prescription, though sharps containers are not always provided.
Clinics may choose to supply or recommend puncture-resistant sharps containers and simple, state-aligned disposal options.
It’s also helpful to establish clear internal steps for escalating patient questions or concerns to a clinician to ensure timely support across virtual and in-person settings.
Documentation Standards
Documentation is crucial to keep a safe and compliant NAD+ treatment program. A compliant program generally includes:
The clinical reasoning for initiating therapy
Form and route of administration
Patient education provided
Follow-up and refill criteria
How to Prescribe Sermorelin in a Compliant, Virtual-First Model
Sermorelin is often simpler to add than NAD+ because it aligns naturally with virtual-first care models.
Baseline Evaluation
Clinicians typically begin with:
A review of wellness goals, history, and medications
At least one lab related to growth hormone pathways—often IGF-1, a biomarker used to understand baseline activity
Self-Administration Workflow
When offering a telehealth or hybrid program, it’s important to include education and training materials to ensure correct administration and usage. A structured Sermorelin program includes:
Training on subcutaneous injection technique
Clear guidance on storage and timing
Written instructions for safe home use
Predictable follow-up for assessing progress and managing refills
Pharmacy and Supply Chain Coordination
Because Sermorelin is often compounded, clinics should:
Partner with vetted 503A (patient-specific compounding) or 503B (outsourcing facility) pharmacies
Request Certificates of Analysis (COAs) when appropriate
Maintain lot-to-patient tracking, meaning each medication batch is linked to a specific patient in case of recall
Confirm any storage requirements, including refrigeration for certain formulations
Longevity Medications Compliance Essentials
A strong compliance framework supports safe, scalable longevity programs.
Licensure and Telehealth Standards
Clinicians must be licensed in every state where patients are located. Because these therapies are often used off-label, documentation and clinician oversight are especially important.
Informed Consent
Consent materials should clearly outline:
How the therapy is used in longevity care
Off-label use
Compounded status when applicable
Follow-up expectations
Avoid disease-treatment language or guaranteed outcomes.
Malpractice Coverage
Clinics should verify that their malpractice policy specifically covers:
Peptides
NAD+ and nutrient injections
Compounded medications
Many wellness and longevity clinics discover their existing coverage does not automatically extend to these specific therapies. Confirming coverage and consulting legal counsel is recommended when expanding service offerings.
Integrating NAD+ and Sermorelin Into an Existing Clinic
For clinics already offering metabolic health, HRT, weight management, or wellness services, NAD+ and Sermorelin can integrate naturally into structured programs.
Define Where the Therapies Fit
Determine whether they belong in energy support, healthy aging pathways, recovery programs, or sleep-focused offerings. This helps avoid ad-hoc, inconsistent prescribing.
Develop Clear Program Packages
Bundled programs improve consistency and give patients clearer expectations around follow-ups, refills, and outcomes.
Standardize Clinical Workflows Across All Providers
When clinicians follow different criteria or timelines, documentation and compliance risk increase. Standardized workflows support operational safety and clear expectations.
Build Predictable Follow-Up and Refill Cadences
Most clinics schedule follow-ups every 4–12 weeks, depending on the therapy and delivery route.
When To Consider a Clinical Operations Partner
If your clinic plans to expand into multiple states or doesn’t have the internal bandwidth to build compliant NAD+ and Sermorelin workflows, a partner like OpenLoop can support:
Nationwide licensed clinicians
Pre-built, telehealth workflows and protocols designed for longevity care
Pharmacy and lab integrations and fulfillment
24/7/365 patient support infrastructure
This allows your clinic to scale responsibly while maintaining a consistent, high-quality patient experience.
Ready to expand your longevity offerings?
Reach out to our team to learn how we can help you launch or scale safely.
*This content is intended for general informational purposes only and should not be construed as legal advice. For guidance on your specific situation, please consult a licensed attorney.