Step-By-Step Guide For How To Start a TRT Company
Step-by-step checklist to launch your TRT telehealth or clinic-based brand the right way.
Starting a Testosterone Replacement Therapy (TRT) company is hot right now. Why? Demand is exploding and many believe the market is underserved. In fact, 40% of men aged under 40 years have expressed interest in Testosterone Replacement Therapy while only 14% are using or have previously used TRT. From 2018 to 2022, the usage of TRT increased across all age demographics:
≤24 years increased by 120%
25–34 years increased by 86%
35–44 years increased by 45%
45-54 years increased by 35%
55–64 year increased by 17
≥65 years increased by 12%
(https://www.uspharmacist.com/article/nationwide-patterns-in-testosterone-replacement-therapy 2025)
What is Testosterone Replacement Therapy (TRT)?
First, let’s define testosterone. Testosterone is a hormone primarily produced in men that plays a critical role in:
Sex drive (libido)
Sperm production
Muscle and bone mass
Fat distribution and weight management
Mood and energy
Red blood cell production
TRT is a medical treatment used to restore healthy testosterone levels in individuals who have low or deficient testosterone, a condition known as hypogonadism.
What type of TRT company should you start?
You have a few options. The table below breaks down your choices and lists some pros and cons of each TRT company business model.
Start a Telehealth TRT Brand
Pros
Fully virtual with minimal overhead costs.
Fast time to market. Can be as fast as a few weeks.
Your total addressable market is significantly larger.
May offer a more discreet visit for sensitive health treatments.
Can partner with a white-label telehealth partner to handle clinician visits, compliance, TRT medication fulfillment, and lab testing.
Cons
Some customers prefer to receive in person medical care.
You may need to have or hire proficiency in digital marketing.
Start a Brick-and-Mortar TRT Clinic
Pros
Appeal to the segment of customers who prefer to get in person medical care.
Lab testing turnaround times may be faster.
May be able to deliver medication with on-site injections.
Cons
Much higher overhead costs such as rent and additional staff.
It generally takes longer to launch your clinic.
Confined to a small geographical target market.
Start a Hybrid TRT Model
Pros
Can appeal to customers who prefer face to face relationships without limiting yourself to a set geographical market.
Your TRT telehealth branch can get to market faster to gain momentum.
Cons
Much higher overhead costs such as rent and additional staff.
May have increased business complexity.
How much money can you make with a TRT company?
This is the ultimate “it depends” question. However, TRT companies often have excellent margins. Here are a few factors that may influence how much money you make:
Do you have a brand niche or value added service around your TRT offering? Strong brands and value added services may be able to charge more.
Are you taking on expensive overhead with an in person TRT clinic or going with a lean TRT telehealth model? Patients under 40 can be more likely to seek flexible and convenient healthcare solutions.
Are you hiring and training your own licensed clinicians or accessing clinicians through a white labeled telehealth platform? Working with a telehealth platform may lower costs by eliminating recruitment costs, benefits, and ensuring you’re not paying for hours without appointments.
Are you cross or upselling additional products such as Erectile Dysfunction (ED) medication, hair loss medication, or GLP-1s? Selling additional products to your current customers is one of the best ways to expand margins.
Are you handling customer support in house or offloading this to a white label telehealth partner?
Are you going to use a subscription model? Monthly auto-bill may smooth out cash flow and increase LTV (lifetime value).
What are the legal and regulatory compliance considerations?
TRT is a controlled substance in the U.S. (Schedule III), so the sale and prescription are regulated by the DEA.
Partner with licensed prescribers (Medical Doctors or Nurse Practitioners) with the appropriate state licenses for your operations.
Ensure compliance with state-specific telehealth laws (some states may require in-person visits for controlled substances).
Follow the Ryan Haight Act.
Use DEA-registered pharmacies for fulfillment.
Ensure any systems that touch patient data are HIPAA-compliant.
Be sure to research and understand your state's marketing and advertising rules.
For a quick overview of some common telehealth compliance considerations, check out “Must Know Telehealth Rules To Keep Your Business Compliant.”
What technology do you need to launch a TRT brand?
This will differ depending on your business model, but a few core items to consider:
A professional website built for conversion rate optimization and search engine optimization. Consider WordPress or WebFlow.
A patient intake form that can collect patient information, screen out patients who don’t qualify, and help schedule a telehealth appointment with the right licensed clinician.
Electronic Health Record (EHR) software, which is an electronic version of a patient's medical history.
Email and text/SMS software to communicate with your patients both pre and post sale.
TIP: consider working with a white label telehealth provider like OpenLoop who can handle parts of the technology set up for you!
Build your TRT brand thoughtfully
In thinking through your brand, keep this famous quote by Meredith Hill in mind:
“When you speak to everyone, you speak to no one.”
So who is your brand going to speak to? Is it really all men? Or is there a segment of men that you know better than anyone else? Focus on the audience you know best and speak directly to them. You’ll stand out in the crowd and possibly attract more loyal customers. A few ideas of “segments” of men to get you started are
Biohackers
Fitness enthusiasts
Executives
Aging men
Also, consider future offerings when branding. Overuse of “T” or “Testosterone” in your collateral may limit your growth into other verticals like Hormone Replacement Therapy (HRT) for women, GLP-1s, hair loss, or ED medication.
Build your TRT Go-to-Market strategy
Now that you’ve locked in your brand and defined your target market, how will you find them? Here are a few of the top marketing acquisition channels for your new TRT telehealth company:
SEO & content marketing: Start with "symptoms of low T," “TRT benefits,” etc. If you have a local presence, create pages dedicated to your market. For example, a TRT clinic in Dallas-Fort Worth may have separate pages for Dallas and Fort Worth.
Meta ads: Focus on your ad creative. Make it speak directly to your ideal buyer. The algorithm is built to find those who respond to your creative.
Google ads: Capture the interest of those currently in-market for TRT. Consider using demographic targeting features to show search ads to those in your target market.
Conversion rate optimization (CRO) testing: Test relentlessly until you find what resonates with your target TRT audience. For telehealth CRO tips, check out this short guide.
Influencer partnerships: Especially in fitness, men’s health, or longevity.
Business partnerships: Find businesses that share your ideal customer to gain low cost marketing distribution. Think gyms and life coaches.
Email/SMS nurture: Convert leads who may need to do a little research. TRT isn’t always a spur of the moment purchase.
Referral program: Offer account credits for referring a friend.
Want to dive further into telehealth marketing? Get The Complete Guide to Marketing Your Telehealth Business here.
What to look for in a white-label telehealth TRT partner
When starting your own TRT telehealth company, partnering with a white-label telehealth company has many advantages, however, not all platforms are the same. Here are a few key things to consider:
How big is the telehealth company’s clinician network? As your brand grows, will they be able to scale with you?
What are their reviews from patients like? To a patient, your telehealth partner’s offering will be seen as an extension of your own brand.
What is their pricing like? Does your telehealth partner have the scale to negotiate a good TRT price on your behalf?
Do they offer the medication and services you may want to offer down the road such as Hormone Replacement Therapy (HRT), GLP-1s, ED medication, and hair loss medication?
Are they a trusted partner who you can rely upon to help keep your business compliant?
Do they offer 24/7/365 support? When your customers have questions, they need answers. Be sure your partner will be ready.
Step-by-step launch checklist to launch your TRT telehealth or clinic-based brand the right way.
Planning & Market Research
Define your business model: Telehealth, Brick & Mortar, or Hybrid
Identify your target demographic (e.g., men 30–55, fitness audience, biohackers)
Validate demand with keyword research and competitor analysis
Define your brand voice and long-term product roadmap (e.g., GLP-1s, ED meds)
Legal, Regulatory & Compliance
Reminder: Please consult with your legal team to ensure you are in compliance with all applicable laws, regulations, and industry standards.
Form your legal entity (LLC, S-Corp, etc.) and register your business
Obtain NPI, state licenses (or partner with those who have them)
Partner with licensed MDs or NPs in each state of operation
Ensure DEA compliance — TRT is a Schedule III controlled substance
Understand the Ryan Haight Act (in-person visit rules for controlled substances)
Use DEA-registered pharmacies for medication fulfillment
Ensure HIPAA compliance across all platforms and vendors
Research state-specific telehealth and advertising rules
Clinician & Pharmacy Setup
Decide: In-house providers vs. white label telehealth partner
Vet white label partners (OpenLoop, Wheel, etc.) for licensing, scalability, reviews
Confirm partner offers the full service scope: TRT, labs, shipping, patient messaging
Decide on pharmacy fulfillment model (compounded vs commercial, mail order vs local)
Tech Stack & Patient Workflow
Build a conversion-optimized website (consider Webflow, WordPress)
Create or integrate an online intake form with clinical screening logic
Set up an EHR (Electronic Health Record) platform
Implement payment processor and subscription billing logic
Set up automated SMS/email workflows (pre-appointment, onboarding, renewals)
Enable secure patient messaging and documentation access
Go-To-Market Strategy
Create SEO content around “low testosterone symptoms,” “TRT for men,” etc.
Launch paid ads: Google Search + Meta (Instagram/Facebook)
Build lead nurture automation (email + SMS drip campaigns)
Launch referral program with incentives for customers
Partner with influencers in fitness, men’s health, or longevity
Set up tracking for KPIs (CAC, LTV, conversion rate, churn, etc.)
Financial Model & Operations
Estimate your CAC (customer acquisition cost) and breakeven point
Plan monthly recurring revenue via subscriptions
Decide on your pricing model: bundled (visit + lab + med) or à la carte
Explore upsells: ED meds, GLP-1s, hair loss treatments, etc.
Determine if you'll insource or outsource customer support
Branding & Trust
Secure your .com domain and professional logo
Write a clear value proposition on homepage and landing pages
Collect early testimonials and reviews (Google, Trustpilot, etc.)
Ensure privacy policy and terms of service are up to date
Create educational content (videos, blogs, FAQs) to build authority
Ready to Launch?
Soft launch with test patients or in a limited market
Monitor legal/regulatory updates monthly
Optimize conversion funnel weekly based on performance
Plan for scale: more states, additional products, advanced campaigns
Pro Tip: Want a shortcut? Partner with a trusted white label platform like OpenLoop to streamline compliance, technology, clinicians, and fulfillment — so you can focus on scaling.
Build your dream TRT company with OpenLoop
OpenLoop is the leading white label telehealth provider with over 20,000 licensed clinicians supporting over 250k patient visits per month. With OpenLoop, your patients will be in good hands, proven by our 4.9/5 star TrustPilot rating.
We know TRT, we know telehealth, and we know how to scale. Ready to build your dream TRT business? Let’s talk.
*This content is intended for general informational purposes only and should not be construed as legal advice. For guidance on your specific situation, please consult a licensed attorney.